Aging is a complex, progressive process throughout life, accompanied by the gradual degradation of human organs and functions, but also significantly increases the risk of chronic diseases, such as cardiovascular disease, diabetes and Alzheimer's disease.
In the field of anti-aging, wormwood, as an important part of traditional Chinese medicine culture, has a long history and diversified functions. More and more studies have shown that wormwood extract contains rich bioactive ingredients, including flavonoids, polysaccharides, organic acids, etc., and has significant medicinal and health care value. Among them, flavonoids have a strong antioxidant effect, they can remove free radicals in the body, slow down the aging process of cells.
At the same time, mugwort leaf can also improve the body's immunity, enhance skin elasticity, and keep the skin hydrated and glossy, so as to achieve anti-aging effects from the inside out.
Previous studies have initially found that wormwood has an anti-aging effect on the model organism, the fly, and the latest scientific research has further revealed its life-prolonging mechanism.
The multiple effects of wormwood
On December 24, 2024, Researchers from Jingchu Institute of Technology and Louisiana State University published a paper in the journal npj Science of Food entitled "Molecular mechanism of culinary herb Artemisia argyi in promoting. lifespan and stress tolerancece "research paper.
Studies have shown that Artemisia argyi leaf extract has anti-aging effects and can extend the life span of nematodes by 23.19%! In addition, wormwood can extend life and improve health in a number of ways.
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In this study, the researchers used a nematode model to analyze the effects and mechanisms of Artemisia argyi extract in prolonging life and enhancing antioxidant stress.
They first identified a total of 22 flavonoids in artemisia argyi leaf extract, including kaempferol, L-epicatechin, apigenin, catechin, quercetin, luteolin, ononolin and naringin.
Next, the researchers treated the nematodes with different concentrations of wormwood leaf extract, including 60, 240 and 360μg/mL. Compared with the control group, the life span of C. elegans was extended by 12.06%, 23.19% and 19.07%, respectively, indicating that the extract of Artemisia sinensis can extend the life span of C. elegans by 23.19%.
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By analyzing the reasons, researchers said that the flavonoids in mugwort kaempferol, quercetin, etc., have powerful antioxidant effects, can effectively neutralize free radicals in the body, reduce the damage of oxidative stress on cells, and delay the decline of organs and tissues.
In addition, wormwood extract significantly improved the locomotion ability and pharyngeal pumping ability of C. elegans, and significantly reduced the accumulation of lipofuscin in C. elegans, which usually represents the aging and functional decline of cells, and the effect of wormwood effectively delayed this process.
Further mechanism analysis showed that Artemisia argyi extract activated the transcription factor DAF-16/FOXO by regulating the insulin /IGF-1 signaling (IIS) pathway
RNA sequencing analysis showed that Artemisia mugwort extract exerts life-prolonging effect mainly through regulating MAPK pathway, because the genetic changes of nematodes treated with Artemisia Mugwort extract are related to antioxidant stress, cell maturation, immune response and stress.
It is important to note that the inflammatory response in the body is often increased during aging, and the anti-inflammatory properties of wormwood help to reduce this inflammatory response, which in turn reduces the risk of chronic diseases associated with aging, such as cardiovascular disease and diabetes.
02. Telomere extension by 20%, known as the "elixir of youth"?
In fact, as early as 2022, scientists in Taiwan found through research that wormwood has the ability to clear aging cells for 48 hours, especially at high concentrations (400 mg/ml), and the telomere length of aging cells is extended by nearly 20%. This means that a 70-year-old has reached a youthful state in his mid-40s.
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To further test this conclusion, the researchers selected 15-month-old male rats (equivalent to 56 human years) as experimental subjects. The results found that these "middle-aged mice" also showed clear signs of reverse aging, their telomere growth trends matched the results of the cell experiment, and also showed a youthful trend in physiological indicators such as memory, hair state and heart and lung function.
The discovery of mugwort leaf extract by Taiwanese scientists undoubtedly provides a new opportunity for the rise of traditional Chinese medicine. Although Artemisia argyi extract can extend the telomere length of cells, this is only part of its anti-aging mechanism. At present, the specific mechanism of action, safety and long-term effects of Artemisia argyi extract are still a long way from practical application.
Therefore, it is not recommended that you try to use it on your own, and you should not regard wormwood extract as an "elixir of life".
epilogue
In summary, wormwood, as a traditional Chinese medicine plant, may become an important natural resource for delaying aging and preventing age-related diseases due to its antioxidant, anti-inflammatory and immunomodulatory properties. In the future, further research around wormwood may help develop new anti-aging and health promotion products.
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