Usually, the crushing process is mainly completed by using external mechanical forces to partially destroy the cohesion between the molecules of the material. That is to use mechanical methods to increase the surface area of the drug, that is, the process of transforming mechanical energy into surface energy, and whether this transformation is complete directly affects the efficiency of crushing.
Crushing requirements are mainly the requirements of crushing degree. The degree of comminution refers to the fineness of the material after comminution, which is an important indicator to check the effect of comminution operation. It is inversely proportional to the average diameter of the material particles after comminution, that is, the smaller the particles after comminution, the greater the degree of comminution. The size of the crushing degree generally depends on the production requirements, medical use and the nature of the drug itself. Over-crushing is not necessarily helpful. Attention should be paid to the adverse phenomena and problems that may be caused by the crushing process, such as thermal decomposition, adhesion, reagglomeration and poor fluidity.
The micro technology of Chinese medicinal materials will drive the innovation of Chinese medicine preparation technology, the quantum force will be generated between micron particles, and the short fiber of a certain size can be used as a relief agent, which reduces the cost on the one hand, reduces the volume on the other hand, and reduces the dosage. The ultrafine raw pharmaceutical powder can be directly used in the manufacture of Chinese medicine, film agent and ointment, cosmetics, etc., which can greatly improve the quality of the preparation.
At present, the ultrafine technology of Chinese medicinal materials has just emerged in China, and there are some problems in the methods of particle classification, particle size determination and wall breaking rate determination. When we study Chinese medicinal materials, we often ignore the particularity of Chinese medicinal materials, which affects the further development of the technology to a certain extent.
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