1. Dry pressing (i.e. the material is dry powder material)
Through the tablet press for dry pressing, dry pressing includes crystal pressing method, dry grain pressing method and powder direct pressing method 3.
1. Crystal tablet method
A certain part of the fluidity and pressure are good crystalline drugs, only need to be properly crushed, screened and dried, and then add an appropriate amount of disintegrants, lubricants can be pressed into tablets, such as potassium chloride, sodium chloride, ferrous sulfate, etc.
2. Dry granulation
The compressibility and fluidity of a certain part of the drug are not good, and the method of granulating mechanism should be first used to improve it, but these drugs are more sensitive to humidity and heat, and are not stable enough, so the dry granulation method can be used to press tablets. The process is: After the drug powder and the necessary auxiliary materials are mixed evenly, it is pressed into a solid (block, flake or granular) with the appropriate equipment, and then crushed into dry particles of the appropriate size, and finally pressed into tablets. Usually a hydraulic press is used to press the mixture of drugs and excipients into a thin sheet solid, but also a special tablet press with greater pressure can be used to press a large sheet (also known as the "large press method"), and then broken into small particles after the tablet.
3. Powder pressing directly
The advantages of this method include saving time and energy, simple process, reduced process, and suitable for unstable drugs under hot and humid conditions. The excipients used have quite good compressibility and fluidity, and can still maintain this good performance of the material after mixing with a certain amount of drugs. The pharmaceutical excipients that can be used for powder direct pressing include microcrystalline cellulose, spray-dried lactose, calcium hydrogen phosphate dihydrate, compressible starch, micro-powdered silica gel (excellent flow aid), etc.
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